Role of TGF-b1 on the IgE-Dependent Anaphylaxis Reaction

Skin Reaction without Systemic Anaphylaxis but Mast Cell-Dependent Immediate-Type Vaccine Peptides Elicit an IgE-Independent Nonmutated Self-Antigen-Derived Cancer

Alternative Anaphylactic Routes: The Potential Role of Macrophages

Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphy...

Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice

Anaphylaxis is a severe systemic allergic reaction which is rapid in onset and potentially fatal, caused by excessive release of mediators including histamine and cytokines/chemokines from mast cells and basophils upon allergen/IgE stimulation. Increased prevalence of anaphylaxis in industrialized countries requires urgent needs for better understanding of anaphylaxis. However, the pathophysiol...

TGF-b1 DNA Polymorphisms, Protein Levels, and Blood Pressure

Transforming growth factor-b1 (TGF-b1), a multifunctional cytokine with fibrogenic properties, has been implicated in the pathogenesis of the vascular and target organ complications of hypertension. TGF-b1 may also regulate blood pressure via stimulation of endothelin-1 and/or renin secretion. Herein we explored the hypothesis that circulating levels of TGF-b1 protein (quantified using a TGF-b1...

Regulatory CD4+Foxp3+ T Cells Control the Severity of Anaphylaxis

OBJECTIVE Anaphylaxis is a life-threatening outcome of immediate-type hypersensitivity to allergen, consecutive to mast cell degranulation by allergen-specific IgE. Regulatory T cells (Treg) can control allergic sensitization and mast cell degranulation, yet their clinical benefit on anaphylactic symptoms is poorly documented. Here we investigated whether Treg action during the effector arm of ...